News

LipidQuant 1.0 tool for automated processing of lipidomic data

The LipidQuant 1.0 tool for automated data processing workflows in lipidomic quantitation based on lipid class separation coupled with high-resolution mass spectrometry is freely available for use to everyone in the scientific community.

Preprints of our latest manuscripts in peer-review process

• Plasma Lipidomic Profiles of Kidney, Breast, and Prostate Cancer Patients Differ from Healthy Controls posted on Research Square on June 22, 2021, submitted to Scientific Reports
• LipidQuant 1.0: automated data processing in lipid class separation - mass spectrometry quantitative workflows posted on Zenodo on June 4, 2021, Bioinformatics, revision submitted
• Retention dependences support highly confident identification of lipid species in human plasma by reversed-phase UHPLC/MS posted on bioRxiv on May 18, 2021, accepted in Anal. Bioanal. Chem. on June 18, 2021
• Lipidomic profiling of human serum enables detection of pancreatic cancer posted on medRxiv on January 26, 2021, 1. revision submitted to Nat. Com.
• Profiling the Lipidome requires quality control posted on Zenodo on April 9 26, 2021, accepted in Nat. Com.

Pozvánka pro studenty - přidej se k nám! and in English Welcome for students - join to us!

Nabídka doktorských, diplomových a bakalářských prací

• Baví vás analytická chemie a jde Vám dobře práce v analytických laboratořích?
• Máte chuť něco dokázat?
• Chcete se podílet na zajímavém výzkumu při vývoji včasné diagnostiky pro nádorová onemocnění?
• Chcete pracovat v mladém kolektivu, kde kromě práce je řada dalších mimopracovních aktivit?
• Domluvíte se aspoň na základní úrovni anglicky?

Pokud ano, tak výborně, to jste na správném místě. Pokud Vás zaujmou témata vypsaných studentských prací, tak se přijďte za námi podívat, rádi Vám ukážeme laboratoře a probereme, co Vás bude zajímat.

Call for students

• Are you interested in some exciting research in the area of lipid cancer biomarkers?
• Do you want to do PhD in the field of analytical chemistry?
• Are you familiar with chromatography and mass spectrometry, at least at basic level?

Great, you may be interested in Ph.D. study in our group. Please look at our topics and write me, if you are interested.

Or you already have your Ph.D. degree in analytical chemistry or biochemistry, and you are looking for postdoc stay. Then you can send me your CV and motivation letter, and I will check our possibilities for the most interesting applications.

KEY RECENTLY PUBLISHED PAPERS AND PATENTS

• Anal. Bioanal. Chem. (2021) in press. Retention dependences support highly confident identification of lipid species in human plasma by reversed-phase UHPLC/MS
• Talanta 231 (2021) 122367. Intra-laboratory cross-comparison of four lipidomic quantitation platforms using hydrophilic interaction liquid chromatography vs. supercritical fluid chromatography coupled to two quadrupole - time-of-flight mass spectrometers.
• Metabolites 11(3) (2021) 140. Structural Characterization of Glycosphingolipids in Human Plasma using Hydrophilic Interaction Liquid Chromatography – Electrospray Ionization Mass Spectrometry.
• Anal. Chim. Acta 1137 (2020) 74-84. Determination of one year stability of lipid plasma profile and comparison of blood collection tubes using UHPSFC/MS and HILIC-UHPLC/MS.
• Anal. Bioanal. Chem. 412 (2020) 2375-2388. Validation of lipidomic quantitative methods based on lipid class separation - mass spectrometry: Comparison of supercritical fluid chromatography and hydrophilic interaction liquid chromatography.
• Biochim. Biophys. Acta - Molecul. Cell Biol. Lipids 1865(2020) 158634. Lipidomic characterization of exosomes isolated from human plasma using various mass spectrometry techniques. and Supplementary information.
• Nat. Metab. 1 (2019) 745–747 Lipidomics need more standarization
• European patent EP 3514545 A method for diagnosing pancreatic cancer based on lipidomic analysis of a body fluid